Description
Orexin-A 10mg also known as hypocretin-1, is a neuropeptide that plays a crucial role in regulating wakefulness, arousal, and appetite. It is produced in the lateral hypothalamus and is involved in maintaining normal wakefulness, as its deficiency can lead to narcolepsy. Orexin-A also influences other functions like mood, reward processing, and stress response.
Here’s a more detailed look at Orexin-A:
Key Roles:
- Wakefulness and Arousal: Orexin-A is essential for maintaining wakefulness and promotes arousal. It does this by activating the locus coeruleus, a brain region involved in arousal and alertness.
- Appetite Regulation: Orexin-A is involved in regulating food intake and energy balance.
- Reward Processing: It plays a role in the brain’s reward system and influences reward-seeking behaviors.
- Mood and Emotion: Orexin-A can influence mood and may be involved in emotional regulation.
- Stress Response: It is involved in the body’s stress response and may impact stress resilience.
Orexin-A and Sleep:
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Narcolepsy:Loss of orexin-producing neurons can lead to narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks.
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REM Sleep:Orexin-A helps regulate REM (Rapid Eye Movement) sleep. Deficiency of orexin can lead to poor control of REM sleep, which can cause cataplexy (sudden muscle weakness) and sleep paralysis, according to Harvard Sleep Medicine.
Orexin-A and Other Functions:
- Cognition and Memory: Orexin-A is involved in learning, memory, and spatial abilities.
- Sympathetic Nervous System: Orexin-A influences the sympathetic nervous system, which is involved in regulating heart rate, blood pressure, and other autonomic functions.
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