Anti OX

Description

Anti OX

Ingredients

30ml

Each drop contains approximately:

Methylene Blue (MB), USP: 0.4mg (400mcg)
Caffeine, USP: 0.4mg (400mcg)
Salicylic acid (2-OH-benzoic acid), USP: 0.4mg (400mcg)
Vit c 200mg

References:
Stimulation of respiration by methylene blue in rat liver mitochondria. – PubMed – NCBI
“…The effect of methylene blue on isolated rat liver mitochondria in the presence and absence of chloroacetaldehyde was investigated. Fatty acid oxidation was inhibited by chloroacetaldehyde and subsequently stimulated by methylene blue. Assessment of tightly coupled mitochondria revealed decreasing respiratory control ratios induced by increasing concentrations of methylene blue and methylene blue provoked mitochondrial swelling. In uncoupled mitochondria, methylene blue promoted a concentration-dependent stimulation of respiration. These findings provide evidence that methylene blue, the redox dye currently used as an antidote for encephalopathy associated with alkylating chemotherapy, uncouples oxidative phosphorylation and acts as an electron transfer mediator to stimulate mitochondrial respiration.”

Effects of Caffeine on Metabolism and Mitochondria Biogenesis in Rhabdomyosarcoma Cells Compared with 2,4-Dinitrophenol
“…This work explored the effects on mitochondrial biosynthesis of caffeine and DNP in human rhabdomyosarcoma cells, a model organism for metabolic observation. We show that treatment of muscle cells with caffeine or DNP will induce the PGC-1α mRNA and protein in a dose- and time-sensitive manner. We also demonstrate that caffeine or DNP increases mitochondrial content as well as enhances oxidative and total metabolism. These are the first observations that directly compare caffeine with DNP and demonstrate the effects of both treatments on glycolytic and oxidative metabolism in skeletal muscle cells.”

Mitochondrial uncouplers with an extraordinary dynamic range
“…The wide dynamic range of uncoupling by BHT and benzoic acid provides an excellent starting point for the design of novel uncouplers that could be used to modulate the burning of calories in humans for the treatment of obesity. The production of reactive oxygen species decreases strongly when the mitochondrial protonmotive force is lowered even slightly by uncoupling [39–41]. These uncouplers therefore also present an alternative approach to decreasing radical generation and perhaps treating age-related disorders, particularly since BHT and mitoBHT have antioxidant as well as uncoupling properties.”
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Some people may wonder why I added benzoic acid. Well, it looks like benzoic acid has a number of cool properties. First, it uncouples mitochondria in extremely low concentrations (less than 1 picoM/L) and that uncoupling capacity does NOT increase much with dosage. So, it has a much higher therapeutic index (e.g. ratio of effectiveness / risk) compared to drugs such as DNP which can kill you if you miscalculate the dosage just a bit. Benzoc acid also reduces ammonia levels by chelation and is approved as an ammonia-reducing drug called Ucephan.
Drugs@FDA: FDA Approved Drug Products
Benzoic acid
“…Benzoic acid is a Nitrogen Binding Agent. The mechanism of action of benzoic acid is as an Ammonium Ion Binding Activity.